In some patients with plasma cell dyscrasia and neuropathy, there are IgM M proteins that react with the myelin-associated glycoprotein (MAG). We used an enzyme-linked immunosorbent assay (ELISA) system to detect anti-MAG IgM antibodies. Reactivity with human MAG by ELISA correlated with demonstration of anti-MAG IgM antibodies by the "immunoblot" technique. Human MAG was more effective than bovine MAG as antigen, and there was no significant reactivity with mouse MAG. The ELISA system is a simple and convenient method for detecting anti-MAG IgM antibodies.
|Titolo:||Anti-MAG IgM antibodies in patients with neuropathy and IgM M proteins: detection by ELISA|
NOBILE-ORAZIO, EDUARDO (Primo)
|Parole Chiave:||Myelin-Associated Glycoprotein; Myelin Proteins; Demyelinating Diseases; Humans; Enzyme-Linked Immunosorbent Assay; Paraproteinemias; Immunoglobulin M; Antibodies, Anti-Idiotypic|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||lug-1983|
|Appare nelle tipologie:||01 - Articolo su periodico|