Increased titers of IgG anti-GM1 and anti-asialo GM1 (GA1) ganglioside antibodies are present in some patients with the Guillain-Barré syndrome, particularly with the motor axonal variant, and following infection with Campylobacter jejuni or parenteral administration of gangliosides. The subclass distribution of IgG anti-GM1 or GA1 antibodies from 19 patients with acute motor neuropathy and elevated antibody titers were measured by ELISA using mouse monoclonal antibodies specific for human IgG subclasses. The anti-GM1 or GA1 antibodies were predominantly of the IgG1 and IgG3 subclasses, which are capable of complement fixation, and are characteristic of a T cell-dependent antibody response.
|Titolo:||IgG anti-GM1 antibodies from patients with acute motor neuropathy are predominantly of the IgG1 and IgG3 subclasses|
NOBILE-ORAZIO, EDUARDO (Secondo)
|Parole Chiave:||Polyradiculoneuropathy; Campylobacter Infections; Humans; Campylobacter jejuni; Immunoglobulin G; Enzyme-Linked Immunosorbent Assay; G(M1) Ganglioside; Motor Neuron Disease|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||apr-1995|
|Digital Object Identifier (DOI):||10.1016/0165-5728(94)00190-Y|
|Appare nelle tipologie:||01 - Articolo su periodico|