TSH circadian secretion rhythm and its changes after the response after exogenous TRH administration were evaluated in 7 patients, affected by simple goiter, after diurnal (h 7.00) and nocturnal (h 19.00) administration of l-thyroxine (1.8-2.2 μg/kg). TSH surge after nocturnal administration of l-thyroxine was higher than TSH surge diurnal administration (18.75 ± 3% v.s. 113.9 ± 17.2%; P < 0.001). Besides, the increase of TSH response to TRH after nocturnal administration of l-thyroxine was higher than increase after diurnal administration. These results show the need to administer l-thyroxine in the morning (7.00 h) to obtain the best suppressive effect on thyroid gland.

Thyrotropin suppressive therapy and TSH rhythm / G. Lupoli, E. Rampone, B. Cassese, E. Cascone, B. Oliviero, G. Vitale, E. Itto, P. Camuso, G. Lombardi. - In: QUADERNI DI MEDICINA E CHIRURGIA. - ISSN 0393-5930. - 12:2(1996), pp. 107-110.

Thyrotropin suppressive therapy and TSH rhythm

G. Vitale;
1996

Abstract

TSH circadian secretion rhythm and its changes after the response after exogenous TRH administration were evaluated in 7 patients, affected by simple goiter, after diurnal (h 7.00) and nocturnal (h 19.00) administration of l-thyroxine (1.8-2.2 μg/kg). TSH surge after nocturnal administration of l-thyroxine was higher than TSH surge diurnal administration (18.75 ± 3% v.s. 113.9 ± 17.2%; P < 0.001). Besides, the increase of TSH response to TRH after nocturnal administration of l-thyroxine was higher than increase after diurnal administration. These results show the need to administer l-thyroxine in the morning (7.00 h) to obtain the best suppressive effect on thyroid gland.
Settore MED/13 - Endocrinologia
QUADERNI DI MEDICINA E CHIRURGIA
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/183171
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