Previous findings demonstrated an altered pattern of amyloid precursor protein (APP) forms in platelets of Alzheimer disease (AD) patients, compared both with healthy control subjects or patients with non-Alzheimer-type dementia. The present study aims to evaluate whether platelet APP form ratio (APPr) is altered in patients with early stage AD. We selected 40 patients with early stage AD and 40 age-matched healthy controls. Compared with controls (mean±SD=0.91±0.3), mean APPr was decreased in AD (mean±SD=0.46±0.26, p<0.0001). Sixteen very mild AD patients (clinical dementia rating=0.5), identified among the AD group, showed a significant decrease of APPr values (mean±SD=0.50±0.3, p<0.0001). These findings indicate that alteration of APP processing in platelets is an early event and suggest that this assay might be of diagnostic value in differentiating mild AD from normal ageing.

Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms / B. Borroni, F. Colciaghi, P. Corsini, N. Akkawi, L. Rozzini, E. Del Zotto, G. Talarico, F. Cattabeni, G.L. Lenzi, M.M.G. Di Luca, A. Padovani. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 23:5(2002), pp. 207-210.

Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms

F. Colciaghi;F. Cattabeni;M.M.G. Di Luca;
2002

Abstract

Previous findings demonstrated an altered pattern of amyloid precursor protein (APP) forms in platelets of Alzheimer disease (AD) patients, compared both with healthy control subjects or patients with non-Alzheimer-type dementia. The present study aims to evaluate whether platelet APP form ratio (APPr) is altered in patients with early stage AD. We selected 40 patients with early stage AD and 40 age-matched healthy controls. Compared with controls (mean±SD=0.91±0.3), mean APPr was decreased in AD (mean±SD=0.46±0.26, p<0.0001). Sixteen very mild AD patients (clinical dementia rating=0.5), identified among the AD group, showed a significant decrease of APPr values (mean±SD=0.50±0.3, p<0.0001). These findings indicate that alteration of APP processing in platelets is an early event and suggest that this assay might be of diagnostic value in differentiating mild AD from normal ageing.
Amyloid precursor protein; Diagnosis; Early stage Alzheimer disease; Platelets
Settore BIO/14 - Farmacologia
NEUROLOGICAL SCIENCES
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/183079
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