A large range of doses of yohimbine (Y) was administered intracerebroventricularly (ICV) (5-100 μg/rat) or intraperitoneally (IP) (0.35-10 mg/kg) to male rats and the effects on sexual, locomotor and general behavior were evaluated. For both routes there was a clear-cut inverted-U effect (stimulating/depressing), calculable as parabolic regressions on the log of administered doses. The maximal stimulating doses (15 μg/rat ICV and 1 mg/kg IP) significantly shortened mount, intromission and ejaculation latencies and the mean interintromission interval. These data indicate the importance of CNS mechanisms in the sexual effect of Y.
Central effect of yohimbine on sexual-behavior in the rat / M. Sala, D. Braida, M.P. Leone, P. Calcaterra, S. Monti, E. Gori. - In: PHYSIOLOGY & BEHAVIOR. - ISSN 0031-9384. - 47:1(1990), pp. 165-173.
Central effect of yohimbine on sexual-behavior in the rat
M. Sala;D. Braida;
1990
Abstract
A large range of doses of yohimbine (Y) was administered intracerebroventricularly (ICV) (5-100 μg/rat) or intraperitoneally (IP) (0.35-10 mg/kg) to male rats and the effects on sexual, locomotor and general behavior were evaluated. For both routes there was a clear-cut inverted-U effect (stimulating/depressing), calculable as parabolic regressions on the log of administered doses. The maximal stimulating doses (15 μg/rat ICV and 1 mg/kg IP) significantly shortened mount, intromission and ejaculation latencies and the mean interintromission interval. These data indicate the importance of CNS mechanisms in the sexual effect of Y.
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