Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.
Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801 / F. Fumagalli, R. Molteni, F. Bedogni, M. Gennarelli, J. Perez, G. Racagni, M. Riva. - In: NEUROREPORT. - ISSN 0959-4965. - 15:13(2004), pp. 2109-2112.
|Titolo:||Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801|
FUMAGALLI, FABIO (Primo)
MOLTENI, RAFFAELLA (Secondo)
RACAGNI, GIORGIO ANGELO (Penultimo)
RIVA, MARCO ANDREA (Ultimo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||2004|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/00001756-200409150-00022|
|Appare nelle tipologie:||01 - Articolo su periodico|