We have investigated the role of dopaminergic receptors in modulation of basic fibroblast growth factor (FGF-2) expression in rat prefrontal cortex and hippocampus, two brain regions important for cognition. We found that FGF-2 expression is upregulated by quinpirole, a D2 agonist, in prefrontal cortex and to a lesser extent in hippocampus. This modulation was specific for dopamine D2 receptors because no effect was observed when the dopamine D1 and D3 agonists, SKF38393 and 7-OH-DPAT, respectively, were administered. Our findings show that activation of dopaminergic D2 receptors modulates FGF-2 expression in rat prefrontal cortex and hippocampus. Our data highlight the complex modulation of FGF-2 expression in limbic areas pointing to this trophic molecule as a putative target of drugs used against acute and chronic neurodegenerative diseases such as Parkinson's disease. (C) 2003 Wiley-Liss, Inc.
Dopaminergic D2 receptor activation modulates FGF-2 gene expression in rat prefrontal cortex and hippocampus / F. Fumagalli, F. Bedogni, M. Maragnoli, M. Gennarelli, J. Perez, G. Racagni, M. Riva. - In: JOURNAL OF NEUROSCIENCE RESEARCH. - ISSN 0360-4012. - 74:1(2003), pp. 74-80.
|Titolo:||Dopaminergic D2 receptor activation modulates FGF-2 gene expression in rat prefrontal cortex and hippocampus|
FUMAGALLI, FABIO (Primo)
RACAGNI, GIORGIO ANGELO (Penultimo)
RIVA, MARCO ANDREA (Ultimo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||2003|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jnr.10733|
|Appare nelle tipologie:||01 - Articolo su periodico|