Slices from rat CA3 hippocampal area show a 30% decrement in ATPase activity after 35 min of 'in vitro' incubation. Such a drop is accompanied by an alteration of mitochondrial ultrastructure. However, if rats are treated daily with GM1 ganglioside (10 mg/kg during 3 days) both phenomena are fully prevented. These results would suggest a protective effect of gangliosides onto membrane structures under stress conditions.
INVIVO TREATMENT WITH GM1 PREVENTS THE RAPID DECAY OF ATPASE ACTIVITIES AND MITOCHONDRIAL DAMAGE IN HIPPOCAMPAL SLICES / R. BIANCHI, D. JANIGRO, F. MILAN, G. GIUDICI, A. GORIO. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 364:2(1986), pp. 400-404.
INVIVO TREATMENT WITH GM1 PREVENTS THE RAPID DECAY OF ATPASE ACTIVITIES AND MITOCHONDRIAL DAMAGE IN HIPPOCAMPAL SLICES
A. GORIOUltimo
1986
Abstract
Slices from rat CA3 hippocampal area show a 30% decrement in ATPase activity after 35 min of 'in vitro' incubation. Such a drop is accompanied by an alteration of mitochondrial ultrastructure. However, if rats are treated daily with GM1 ganglioside (10 mg/kg during 3 days) both phenomena are fully prevented. These results would suggest a protective effect of gangliosides onto membrane structures under stress conditions.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
