Slices from rat CA3 hippocampal area show a 30% decrement in ATPase activity after 35 min of 'in vitro' incubation. Such a drop is accompanied by an alteration of mitochondrial ultrastructure. However, if rats are treated daily with GM1 ganglioside (10 mg/kg during 3 days) both phenomena are fully prevented. These results would suggest a protective effect of gangliosides onto membrane structures under stress conditions.

INVIVO TREATMENT WITH GM1 PREVENTS THE RAPID DECAY OF ATPASE ACTIVITIES AND MITOCHONDRIAL DAMAGE IN HIPPOCAMPAL SLICES / R. BIANCHI, D. JANIGRO, F. MILAN, G. GIUDICI, A. GORIO. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 364:2(1986), pp. 400-404.

INVIVO TREATMENT WITH GM1 PREVENTS THE RAPID DECAY OF ATPASE ACTIVITIES AND MITOCHONDRIAL DAMAGE IN HIPPOCAMPAL SLICES

A. GORIO
Ultimo
1986

Abstract

Slices from rat CA3 hippocampal area show a 30% decrement in ATPase activity after 35 min of 'in vitro' incubation. Such a drop is accompanied by an alteration of mitochondrial ultrastructure. However, if rats are treated daily with GM1 ganglioside (10 mg/kg during 3 days) both phenomena are fully prevented. These results would suggest a protective effect of gangliosides onto membrane structures under stress conditions.
ganglioside; hippocampus; mitochondrion; Na,K-ATPase
Settore BIO/14 - Farmacologia
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/182996
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 35
social impact