In addition to pyrazinoic acid and 5-hydroxypyrazinoic acid, a new metabolite of the tuberculostatic agent pyrazinamide, 5-hydroxypyrazinamide has been identified after in vitro incubation of the drug with rat liver preparations. The structure of the new metabolite was elucidated by GLC analysis and, after isolation by TLC, by MS analysis. Formation of the metabolite is mediated by soluble Xanthine oxidase and is an alternative pathway for pyrazinamide detoxification by the liver cell.
|Titolo:||In vitro biotransformation of pyrazinamide by rat liver: identification of a new metabolite|
MAFFEI FACINO, ROBERTO (Secondo)
CARINI, MARINA (Penultimo)
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
|Data di pubblicazione:||1981|
|Digital Object Identifier (DOI):||10.1016/S0031-6989(81)80005-7|
|Appare nelle tipologie:||01 - Articolo su periodico|