The metabolism of Bezafibrate, a new lipid lowering drug, was studied in vitro using rat liver subcellular fractions as enzymes source. The drug is metabolized in rat liver microsomes through C-oxidation by a cytochrome P-450 mediated process to hydroxy-Bezafibrate. The extent of hydroxy-Bezafibrate formation is limited, because of the type of Bezafibrate interaction with, and its binding parameters to rat liver cytochrome P-450. The mechanism of hydroxy-Bezafibrate formation by rat liver microsomal cytochrome P-450 is discussed.
|Titolo:||"In vitro" metabolism of bezafibrate by rat liver|
MAFFEI FACINO, ROBERTO (Primo)
CARINI, MARINA (Secondo)
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
|Data di pubblicazione:||1981|
|Digital Object Identifier (DOI):||10.1016/S0031-6989(81)80013-6|
|Appare nelle tipologie:||01 - Articolo su periodico|