The metabolism of Bezafibrate, a new lipid lowering drug, was studied in vitro using rat liver subcellular fractions as enzymes source. The drug is metabolized in rat liver microsomes through C-oxidation by a cytochrome P-450 mediated process to hydroxy-Bezafibrate. The extent of hydroxy-Bezafibrate formation is limited, because of the type of Bezafibrate interaction with, and its binding parameters to rat liver cytochrome P-450. The mechanism of hydroxy-Bezafibrate formation by rat liver microsomal cytochrome P-450 is discussed.

"In vitro" metabolism of bezafibrate by rat liver / R. Maffei Facino, M. Carini, R. Bertuletti, O. Tofanetti. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 13:2(1981), pp. 121-132.

"In vitro" metabolism of bezafibrate by rat liver

R. Maffei Facino
Primo
;
M. Carini
Secondo
;
1981

Abstract

The metabolism of Bezafibrate, a new lipid lowering drug, was studied in vitro using rat liver subcellular fractions as enzymes source. The drug is metabolized in rat liver microsomes through C-oxidation by a cytochrome P-450 mediated process to hydroxy-Bezafibrate. The extent of hydroxy-Bezafibrate formation is limited, because of the type of Bezafibrate interaction with, and its binding parameters to rat liver cytochrome P-450. The mechanism of hydroxy-Bezafibrate formation by rat liver microsomal cytochrome P-450 is discussed.
Settore CHIM/08 - Chimica Farmaceutica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182922
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