Sera from eight of 25 patients with chronic sensory neuropathy had high titers of antibodies to sulfatide and chondroitin sulfate C or both. Preclearing of patients' sera with either sulfatide or chondroitin sulfate C revealed that in four patients the antisulfatide antibodies crossreacted with chondroitin sulfate C. By indirect immunohistochemistry sera reactive to sulfatide only had a different staining pattern from those reactive to both sulfatide and chondroitin sulfate C. By direct immunohistochemistry we found immunoglobulins bound to nerve fibers only in patients with serum antibodies against both sulfatide and chondroitin sulfate C. Our study provides evidence that antibodies to sulfatide and to chondroitin sulfate C differ in their fine specificity and are present in 30% of patients with chronic sensory neuropathy.

Antibodies to sulfatide and to chondroitin sulfate C in patients with chronic sensory neuropathy / R. Nemni, R. Fazio, A. Quattrini, I. Lorenzetti, D. Mamoli, N. Canal. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 43:1-2(1993 Mar), pp. 79-85-85.

Antibodies to sulfatide and to chondroitin sulfate C in patients with chronic sensory neuropathy

R. Nemni
Primo
;
1993

Abstract

Sera from eight of 25 patients with chronic sensory neuropathy had high titers of antibodies to sulfatide and chondroitin sulfate C or both. Preclearing of patients' sera with either sulfatide or chondroitin sulfate C revealed that in four patients the antisulfatide antibodies crossreacted with chondroitin sulfate C. By indirect immunohistochemistry sera reactive to sulfatide only had a different staining pattern from those reactive to both sulfatide and chondroitin sulfate C. By direct immunohistochemistry we found immunoglobulins bound to nerve fibers only in patients with serum antibodies against both sulfatide and chondroitin sulfate C. Our study provides evidence that antibodies to sulfatide and to chondroitin sulfate C differ in their fine specificity and are present in 30% of patients with chronic sensory neuropathy.
Antibodies; Axonal neuropathy; Chondroitin sulfate C; Sensory neuropathy; Sulfatide
Settore MED/26 - Neurologia
Settore MED/04 - Patologia Generale
mar-1993
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182912
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