The alkylation of benzene with @)-methyl 2-[ (chlorosulfonyl)oxy]- or 2-(mesyloxy)propionate, in the presence of aluminum chloride, affords (S)-methyl 2-phenylpropionate in good chemical (5040%) and excellent optical yield (197% as determined by rotation), with inversion of configuration at the attacking carbon atom.
ALKYLATION OF AROMATIC-COMPOUNDS WITH OPTICALLY-ACTIVE LACTIC-ACID DERIVATIVES - SYNTHESIS OF OPTICALLY PURE 2-ARYLPROPIONIC ACID AND ESTERS / O. PICCOLO, F. SPREAFICO, G. VISENTIN, E. VALOTI. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 50:20(1985), pp. 3945-3946.
Titolo: | ALKYLATION OF AROMATIC-COMPOUNDS WITH OPTICALLY-ACTIVE LACTIC-ACID DERIVATIVES - SYNTHESIS OF OPTICALLY PURE 2-ARYLPROPIONIC ACID AND ESTERS |
Autori: | VALOTI, ERMANNO (Ultimo) |
Parole Chiave: | 2-Arylpropionic Acid ; Alkilation ; lactic acid derivatives ; |
Settore Scientifico Disciplinare: | Settore CHIM/08 - Chimica Farmaceutica Settore CHIM/06 - Chimica Organica |
Data di pubblicazione: | 1985 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/jo00220a061 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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