Dehydrocholic acid may be obtained in two polymorphic forms: alpha and beta. The complete characterization and the crystal structure of the beta-phase (obtained by unconventional powder diffraction methods) are described and discussed. Conversion of the alpha-form into the thermodynamically more stable beta-polymorph may be obtained through a room temperature solvent-mediated process. On the other hand, transformation of the beta-form into the alpha-form is realized through two distinct pathways: via a temperature-mediated process or as a guest-mediated solid state conversion, without the intervention of an amorphous state. R-(+)-Methyl p-tolyl sulfoxide is the guest of choice for this unusual beta-to-alpha transformation.

Polymorphism of dehydrocholic acid: crystal structure of the beta-phase and guest-mediated solid phase conversion / G. Fantin, M. Fogagnolo, O. Bortolini, N. Masciocchi, S. Galli, A. Sironi. - In: NEW JOURNAL OF CHEMISTRY. - ISSN 1144-0546. - 27:12(2003), pp. 1794-1800.

Polymorphism of dehydrocholic acid: crystal structure of the beta-phase and guest-mediated solid phase conversion

A. Sironi
Ultimo
2003

Abstract

Dehydrocholic acid may be obtained in two polymorphic forms: alpha and beta. The complete characterization and the crystal structure of the beta-phase (obtained by unconventional powder diffraction methods) are described and discussed. Conversion of the alpha-form into the thermodynamically more stable beta-polymorph may be obtained through a room temperature solvent-mediated process. On the other hand, transformation of the beta-form into the alpha-form is realized through two distinct pathways: via a temperature-mediated process or as a guest-mediated solid state conversion, without the intervention of an amorphous state. R-(+)-Methyl p-tolyl sulfoxide is the guest of choice for this unusual beta-to-alpha transformation.
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Settore CHIM/03 - Chimica Generale e Inorganica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182859
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