Down’s syndrome (DS) is the most frequent chromosomal aberration in men. Moreover DS is considered an atheroma-free model. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-a high sensitivity (hsTNF-a), leptin and adiponectin from non-demented DS subjects of three different age cohorts (2–14, 20–50 and above 60 years) and healthy controls were measured. No clinical and sub-clinical inflammation was apparent in DS patients. Plasma levels of hsTNF-a, IL-6 and leptin were higher in children than in adult and old DS subjects. Instead, serum levels of adiponectin were increased in older DS patients than in DS children and adults. High levels of circulating adiponectin might protect DS from clinical complications of atherosclerosis.

Adipocytokines in Down's sindrome, an atheroma-free model: Role of adiponectin / M. M. Corsi, G. Dogliotti, F. Pedroni, E. Galliera, A. E. Malavazos, R. Villa, M. Chiappelli, F. Licastro. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - 48:1(2009), pp. 106-109. [10.1016/j.archger.2007.10.011]

Adipocytokines in Down's sindrome, an atheroma-free model: Role of adiponectin

M.M. Corsi
Primo
;
E. Galliera;A.E. Malavazos;R. Villa;
2009

Abstract

Down’s syndrome (DS) is the most frequent chromosomal aberration in men. Moreover DS is considered an atheroma-free model. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-a high sensitivity (hsTNF-a), leptin and adiponectin from non-demented DS subjects of three different age cohorts (2–14, 20–50 and above 60 years) and healthy controls were measured. No clinical and sub-clinical inflammation was apparent in DS patients. Plasma levels of hsTNF-a, IL-6 and leptin were higher in children than in adult and old DS subjects. Instead, serum levels of adiponectin were increased in older DS patients than in DS children and adults. High levels of circulating adiponectin might protect DS from clinical complications of atherosclerosis.
Adiponectin; Down's syndrome; Interleukin-6; Leptin; Tumor necrosis factor-α high sensitivity
Settore MED/05 - Patologia Clinica
Settore VET/07 - Farmacologia e Tossicologia Veterinaria
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182843
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