The present data show that the simultaneous exposure to tumor necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma) induces cell death with characteristics of apoptosis in cultured rat oligodendrocytes; TNFalpha alone was ineffective. We have also demonstrated that different corticosteroids (aldosterone, deoxycorticosterone, dexamethasone and corticosterone) protect rat oligodendrocytes in culture from apoptosis induced by TNFalpha plus IFNgamma. This effect seems to be exerted via the interaction with both type I and type II corticosteroid receptors since all steroids considered are effective. Since oligodendrocyte apoptosis represents an important event in multiple sclerosis and in several demyelinating diseases, the present observations might be considered an interesting background for further researches directed to the possibility of controlling in vivo the death of these cells.

Corticosteroids protect oligodendrocytes from cytokine-induced cell death / R.C. Melcangi, I. Cavarretta, V. Magnaghi, E. Ciusani, A. Salmaggi. - In: NEUROREPORT. - ISSN 0959-4965. - 11:18(2000 Dec 18), pp. 3969-3972.

Corticosteroids protect oligodendrocytes from cytokine-induced cell death

R.C. Melcangi
Primo
;
V. Magnaghi;
2000

Abstract

The present data show that the simultaneous exposure to tumor necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma) induces cell death with characteristics of apoptosis in cultured rat oligodendrocytes; TNFalpha alone was ineffective. We have also demonstrated that different corticosteroids (aldosterone, deoxycorticosterone, dexamethasone and corticosterone) protect rat oligodendrocytes in culture from apoptosis induced by TNFalpha plus IFNgamma. This effect seems to be exerted via the interaction with both type I and type II corticosteroid receptors since all steroids considered are effective. Since oligodendrocyte apoptosis represents an important event in multiple sclerosis and in several demyelinating diseases, the present observations might be considered an interesting background for further researches directed to the possibility of controlling in vivo the death of these cells.
Apoptosis; Corticosteroids; IFNγ; In vitro; Oligodendrocytes; Rat; TNFα
Settore MED/13 - Endocrinologia
Settore BIO/09 - Fisiologia
http://journals.lww.com/neuroreport/pages/articleviewer.aspx?year=2000&issue=12180&article=00013&type=abstract
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182836
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