Considering the great pharmacological interest in phenoxy/phenylthioalkanoic esters of open-chain or cyclic aminoalcohols, a set of ten such esters of lupinine was prepared. Initially, their ability to displace [3H]QNB from rat brain preparation was investigated. With the exception of two, all the prepared esters exhibited good affinity to muscarinic receptors (on a non-selective basis), with pKi in the range 6.67-7.68.
2-(4-R-phenoxy/phenylthio)alkanoic esters of l-lupinine / A. Sparatore, F. Sparatore. - In: IL FARMACO. - ISSN 0014-827X. - 56:3(2001 Mar), pp. 169-174.
2-(4-R-phenoxy/phenylthio)alkanoic esters of l-lupinine
A. SparatorePrimo
;
2001
Abstract
Considering the great pharmacological interest in phenoxy/phenylthioalkanoic esters of open-chain or cyclic aminoalcohols, a set of ten such esters of lupinine was prepared. Initially, their ability to displace [3H]QNB from rat brain preparation was investigated. With the exception of two, all the prepared esters exhibited good affinity to muscarinic receptors (on a non-selective basis), with pKi in the range 6.67-7.68.
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