Development of a second lymphoma after autotransplantation is an unusual event. Its real incidence, however, could be underestimated, since histologic and immunophenotyping techniques are often unable to distinguish it from a relapse. We report a lymphoma patient in apparent relapse after 42 months of molecular remission achieved by autotransplantation. Sequencing analysis of the immunoglobulin heavy-chain genes showed that the rearrangement of variable, diversity and joining segments had changed between diagnosis and relapse and suggested that a second lymphoma had developed.
|Titolo:||Analysis of the immunoglobulin heavy-chain gene rearrangement providing molecular evidence of second lymphoma in a patient in apparent relapse after autotransplantation|
CORRADINI, PAOLO (Secondo)
|Parole Chiave:||Neoplasms, Second Primary; Humans; Genes, Immunoglobulin; Lymphoma, Follicular; Gene Rearrangement; Transplantation, Autologous; Recurrence; Base Sequence; Burkitt Lymphoma; Adult; Molecular Sequence Data; Immunoglobulin Heavy Chains; Bone Marrow Transplantation; Male|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||ago-1997|
|Digital Object Identifier (DOI):||10.1038/sj.bmt.1700887|
|Appare nelle tipologie:||01 - Articolo su periodico|