Development of a second lymphoma after autotransplantation is an unusual event. Its real incidence, however, could be underestimated, since histologic and immunophenotyping techniques are often unable to distinguish it from a relapse. We report a lymphoma patient in apparent relapse after 42 months of molecular remission achieved by autotransplantation. Sequencing analysis of the immunoglobulin heavy-chain genes showed that the rearrangement of variable, diversity and joining segments had changed between diagnosis and relapse and suggested that a second lymphoma had developed.

Analysis of the immunoglobulin heavy-chain gene rearrangement providing molecular evidence of second lymphoma in a patient in apparent relapse after autotransplantation / S. Campana, P. Corradini, M. Astolfi, M. Ladetto, F. Cinque, D. Novero, C. Tarella, A. Pileri. - In: BONE MARROW TRANSPLANTATION. - ISSN 0268-3369. - 20:4(1997 Aug), pp. 341-3-343. [10.1038/sj.bmt.1700887]

Analysis of the immunoglobulin heavy-chain gene rearrangement providing molecular evidence of second lymphoma in a patient in apparent relapse after autotransplantation

P. Corradini
Secondo
;
C. Tarella;
1997-08

Abstract

Development of a second lymphoma after autotransplantation is an unusual event. Its real incidence, however, could be underestimated, since histologic and immunophenotyping techniques are often unable to distinguish it from a relapse. We report a lymphoma patient in apparent relapse after 42 months of molecular remission achieved by autotransplantation. Sequencing analysis of the immunoglobulin heavy-chain genes showed that the rearrangement of variable, diversity and joining segments had changed between diagnosis and relapse and suggested that a second lymphoma had developed.
Neoplasms, Second Primary; Humans; Genes, Immunoglobulin; Lymphoma, Follicular; Gene Rearrangement; Transplantation, Autologous; Recurrence; Base Sequence; Burkitt Lymphoma; Adult; Molecular Sequence Data; Immunoglobulin Heavy Chains; Bone Marrow Transplantation; Male
Settore MED/15 - Malattie del Sangue
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/182783
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