The EGF receptor, which is homologous to the v-erb-B oncogene product, has intrinsic tyrosine kinase activity, and mediates an increase in polyphosphoinositide turnover and [Ca2+]i. Recently, great progress has been made in understanding the mechanism of signal transduction at this receptor. Jacopo Meldolesi and colleagues discuss how this knowledge may lead to a better understanding of the control of cell proliferation.
Transmembrane signalling at the epidermal growth factor receptor / A. Pandiella, L. Beguinot, L. M. Vicentini, J. Meldolesi. - In: TRENDS IN PHARMACOLOGICAL SCIENCES. - ISSN 0165-6147. - 10:10(1989 Oct), pp. 411-414.
Transmembrane signalling at the epidermal growth factor receptor
L. M. VicentiniPenultimo
;
1989
Abstract
The EGF receptor, which is homologous to the v-erb-B oncogene product, has intrinsic tyrosine kinase activity, and mediates an increase in polyphosphoinositide turnover and [Ca2+]i. Recently, great progress has been made in understanding the mechanism of signal transduction at this receptor. Jacopo Meldolesi and colleagues discuss how this knowledge may lead to a better understanding of the control of cell proliferation.
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