Pregnant Sprague-Dawley rats received [14C]Carmoisine (200 mg/kg; 25 μCi) by gavage, on days 16-19 of gestation. Animals were killed on day 19 of gestation, 2, 16, 64 h after dosing and blood, maternal tissues, amniotic fluids, placentae, fetal membranes and fetuses were analyzed for radioactivity. No evidence for the transplacental transfer of [14C]Carmoisine or its metabolites was obtained. More than 90% of the radioactivity was excreted in feces and urine within 64 h.

Placental transfer and tissue localization of [14C]carmoisine in the pregnant rat / C.L. Galli, M. Marinovich, L.G. Costa, E. Giavini. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - 10:2-3(1982), pp. 255-258.

Placental transfer and tissue localization of [14C]carmoisine in the pregnant rat

C.L. Galli
Primo
;
M. Marinovich
Secondo
;
E. Giavini
Ultimo
1982

Abstract

Pregnant Sprague-Dawley rats received [14C]Carmoisine (200 mg/kg; 25 μCi) by gavage, on days 16-19 of gestation. Animals were killed on day 19 of gestation, 2, 16, 64 h after dosing and blood, maternal tissues, amniotic fluids, placentae, fetal membranes and fetuses were analyzed for radioactivity. No evidence for the transplacental transfer of [14C]Carmoisine or its metabolites was obtained. More than 90% of the radioactivity was excreted in feces and urine within 64 h.
Pregnant Sprague-Dawley rats received [14C]Carmoisine (200 mg/kg; 25 μCi) by gavage, on days 16-19 of gestation. Animals were killed on day 19 of gestation, 2, 16, 64 h after dosing and blood, maternal tissues, amniotic fluids, placentae, fetal membranes and fetuses were analyzed for radioactivity. No evidence for the transplacental transfer of [14C]Carmoisine or its metabolites was obtained. More than 90% of the radioactivity was excreted in feces and urine within 64 h.
Settore BIO/14 - Farmacologia
http://www.ncbi.nlm.nih.gov/pubmed/7080094
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/182715
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