We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.
Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats / R. Maggio, F. Fumagalli, E. Donati, P. Barbier, G. Racagni, G. U. Corsini, M. Riva. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 679:1(1995 May 08), pp. 184-7-187. [10.1016/0006-8993(95)00217-E]
Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats
F. FumagalliSecondo
;G. Racagni;M. RivaUltimo
1995
Abstract
We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.
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