We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.

Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats / R. Maggio, F. Fumagalli, E. Donati, P. Barbier, G. Racagni, G. U. Corsini, M. Riva. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 679:1(1995 May 08), pp. 184-7-187.

Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats

F. Fumagalli
Secondo
;
G. Racagni;M. Riva
Ultimo
1995

Abstract

We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.
Injections, Intraperitoneal; Animals; Arginine; Seizures; Nitroarginine; Rats; Kainic Acid; Rats, Sprague-Dawley; Nitric Oxide Synthase; Amino Acid Oxidoreductases; Pilocarpine; Drug Synergism; Male
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182682
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