A new chemoenzymatic synthesis of both enantiomers of mevalonolactone 1 starting from the Pseudomonas fluorescens lipase-catalyzed resolution of racemic 2-(3-methyl-2-butenyl)-oxiranemethanol 2 is reported.

A New Synthesis of (R)- and (S)-Mevalonolactone from the Enzymatic Resolution of (R,S)-2-(3-Methyl-2-butenyl)-oxiranemethanol / P. Ferraboschi, P. Grisenti, S. Casati, E. Santaniello. - In: SYNLETT. - ISSN 0936-5214. - :9(1994), pp. 754-756.

A New Synthesis of (R)- and (S)-Mevalonolactone from the Enzymatic Resolution of (R,S)-2-(3-Methyl-2-butenyl)-oxiranemethanol

P. Ferraboschi
Primo
;
S. Casati
Penultimo
;
E. Santaniello
Ultimo
1994

Abstract

A new chemoenzymatic synthesis of both enantiomers of mevalonolactone 1 starting from the Pseudomonas fluorescens lipase-catalyzed resolution of racemic 2-(3-methyl-2-butenyl)-oxiranemethanol 2 is reported.
lipase-catalyzed hydrolysis; chiral building block; organic-synthesis; asymmetric epoxidation; acid lactone; esters; alcohols; route; mevalonolactone; derivatives
Settore BIO/10 - Biochimica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182658
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