UK114 is a tumor antigen expressed by various malignant neoplasms, Tile complete amino acid sequence of UK114 purified from goat liver has been determined by automated Edman degradation of CNBr and endoproteinase Lys-C peptides. The protein contains 137 amino acid residues, which corresponds to a molecular mass of 14229 Da. MALDI-TOF analysis resulted in a molecular weight of 14290, suggesting that the N-terminal Met residue is acetylated, Sequence comparison shows that UK114 from goat liver (1) has 77% identity with a previously described 23 kDa protein from rat liver (Levy-Favatier et al. (1993) Eur. J. Biochem. 212, 665-673), (2) shares a very high degree of similarity with a family of prokaryotic and eukaryotic hypothetic proteins whose function have not yet been characterized, and (3) exhibits a significant similarity to a group of tumor-associated antigens which belongs to a superfamily of heat shock proteins, acting as possible targets for the host's antitumor immunity.
The primary structure of UK114 tumor antigen / F. Ceciliani, L. Faotto, A. Negri, I. Colombo, B. Berra, A. Baertorelli, S. Ronchi. - In: FEBS LETTERS. - ISSN 0014-5793. - 393:2-3(1996), pp. 147-150.
|Titolo:||The primary structure of UK114 tumor antigen|
CECILIANI, FABRIZIO (Primo)
RONCHI, SEVERINO (Ultimo)
|Parole Chiave:||Amino acid sequence; Tumor antigen; UK114|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||1996|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0014-5793(96)00850-2|
|Appare nelle tipologie:||01 - Articolo su periodico|