Plasma lipid/lipoprotein changes were monitored after a fat load (65 g fat per square meter body surface area) in six carriers of the apolipoprotein A- I(Milano) (A-I(M)) variant and six age- and sex-matched control subjects. The magnitude of postprandial lipemia, calculated as the area under the curve (AUC) described by plasma triglyceride (TG) level versus time, was threefold higher in the A-I(M) carriers; however, after correction for the different baseline TG levels, it was similar to control subjects. Moreover, the magnitude of postprandial lipemia was positively correlated with baseline TG in both A-I(M) carriers (r=0.77) and control subjects (r=0.80), indicating that fasting TGs are a major determinant of postprandial response in all subjects. Postprandial lipemia was also inversely correlated with high density lipoprotein (HDL) and HDL2 cholesterol in both groups (A-I(M), r=- 0.81 and -0.79; control subjects, r=-0.87 and -0.94). Different from those in control subjects, the plasma apo A-I levels in the A-I(M) carriers decreased progressively while apo B increased up to 4 hours but decreased thereafter. Postprandial rises of low density lipoprotein TG but not of HDL-TG AUC were significantly higher in the A-I(M) carriers, even after normalization for the different fasting concentrations. These data show that the low plasma HDL levels of A-I(M) carriers, which are secondary to a primary structural alteration of the major HDL apolipoprotein, are associated with elevated fasting and postprandial TG levels and an anomalous postprandial redistribution of TG among lipoprotein classes.

INCREASED POSTPRANDIAL LIPEMIA IN APO A-I(MILANO) CARRIERS / L. CALABRESI, M. CASSINOTTI, G. GIANFRANCESCHI, O. SAFA, T. MURAKAMI, C. SIRTORI, G. FRANCESCHINI. - In: ARTERIOSCLEROSIS AND THROMBOSIS. - ISSN 1049-8834. - 13:4(1993), pp. 521-528.

INCREASED POSTPRANDIAL LIPEMIA IN APO A-I(MILANO) CARRIERS

L. CALABRESI
Primo
;
C. SIRTORI
Penultimo
;
G. FRANCESCHINI
Ultimo
1993

Abstract

Plasma lipid/lipoprotein changes were monitored after a fat load (65 g fat per square meter body surface area) in six carriers of the apolipoprotein A- I(Milano) (A-I(M)) variant and six age- and sex-matched control subjects. The magnitude of postprandial lipemia, calculated as the area under the curve (AUC) described by plasma triglyceride (TG) level versus time, was threefold higher in the A-I(M) carriers; however, after correction for the different baseline TG levels, it was similar to control subjects. Moreover, the magnitude of postprandial lipemia was positively correlated with baseline TG in both A-I(M) carriers (r=0.77) and control subjects (r=0.80), indicating that fasting TGs are a major determinant of postprandial response in all subjects. Postprandial lipemia was also inversely correlated with high density lipoprotein (HDL) and HDL2 cholesterol in both groups (A-I(M), r=- 0.81 and -0.79; control subjects, r=-0.87 and -0.94). Different from those in control subjects, the plasma apo A-I levels in the A-I(M) carriers decreased progressively while apo B increased up to 4 hours but decreased thereafter. Postprandial rises of low density lipoprotein TG but not of HDL-TG AUC were significantly higher in the A-I(M) carriers, even after normalization for the different fasting concentrations. These data show that the low plasma HDL levels of A-I(M) carriers, which are secondary to a primary structural alteration of the major HDL apolipoprotein, are associated with elevated fasting and postprandial TG levels and an anomalous postprandial redistribution of TG among lipoprotein classes.
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182539
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