Background: High-dose chemotherapy (HDC) has been widely utilized in high-risk breast cancer, but it may induce cardiac toxicity. Cardiac dysfunction may become evident weeks or months after HDC and, to date, no early markers of myocardial injury that are able to predict late ventricular impairment are available. We investigated the role of plasma troponin I (TnI) in this setting. Patients and methods: We measured TnI plasma concentration after HDC in 211 high-risk breast cancer women (46 ± 11 years, mean ± SD). According to TnI value (<0.5 or ≥0.5 ng/ml), patients were allocated into a troponin positive (TnI+; n = 70) and a troponin negative (TnI-; n = 141) group. All patients underwent left ventricular ejection fraction (LVEF, Echo) examination during the following 12 months. Results: LVEF progressively decreased in the TnI+ group but not in the TnI- group. In TnI+ patients a close relationship between the TnI increase, as well as the number of positive TnI assays, and the maximal LVEF decrement, was found (r = 0.92, P <0.0001 and r = 0.93, P < 0.0001, respectively). Conclusions: In our population, the elevation of TnI soon after HDC accurately predicts the development of future LVEF depression. In this setting, TnI can be considered a sensitive and reliable marker of myocardial damage with relevant clinical and prognostic implications.
|Titolo:||Myocardial injury revealed by plasma troponin I in breast cancer treated with high-dose chemotherapy|
|Parole Chiave:||Severity of Illness Index; Sensitivity and Specificity; Probability; Neoplasm Staging; Dose-Response Relationship, Drug; Humans; Breast Neoplasms; Cardiomyopathies; Risk Assessment; Heart Function Tests; Prospective Studies; Survival Rate; Logistic Models; Electrocardiography; Adult; Cohort Studies; Antineoplastic Combined Chemotherapy Protocols; Middle Aged; Follow-Up Studies; Troponin I; Biological Markers; Female|
|Settore Scientifico Disciplinare:||Settore MED/11 - Malattie dell'Apparato Cardiovascolare|
|Data di pubblicazione:||mag-2002|
|Digital Object Identifier (DOI):||10.1093/annonc/mdf170|
|Appare nelle tipologie:||01 - Articolo su periodico|