In six anesthetized, paralyzed and mechanically ventilated Large White pigs, systemic (PAM) and pulmonary arterial pressure (PAPM) have been evaluated. With rapid occlusion method, resistances (Rmax,rs, DeltaR,rs and Rint,rs) and elastances (Est,rs and Edyn,rs) of respiratory system have been evaluated during costant flow and volume inflation. Inhaled NO (80 ppm, 6') in control conditions increased static and dynamic elastances, while decreased PAPM. PAF administration (50 ng/kg iv) significantly raised respiratory resistances and elastances, and PAPM. Its effects are counterbalanced by inhaled NO. Results show that inhaled NO may represent a therapeutic strategy to reduce bronchoconstriction and pulmonary hypertension present in obstructive, inflammatory and allergic diseases.

Effetti dell’inalazione di ossido d’azoto nella broncocostrizione e nell’ipertensione polmonare indotte da Platelet Activating Factor (PAF) / M.G. Clement, M. Albertini. - In: ATTI DELLA SOCIETA' ITALIANA DELLE SCIENZE VETERINARIE. - ISSN 1721-1980. - 48(1994), pp. 177-181. ((Intervento presentato al 48. convegno XLVIII Convegno SISVet tenutosi a Giardini Naxos nel 1994.

Effetti dell’inalazione di ossido d’azoto nella broncocostrizione e nell’ipertensione polmonare indotte da Platelet Activating Factor (PAF)

M.G. Clement
Primo
;
M. Albertini
Ultimo
1994

Abstract

In six anesthetized, paralyzed and mechanically ventilated Large White pigs, systemic (PAM) and pulmonary arterial pressure (PAPM) have been evaluated. With rapid occlusion method, resistances (Rmax,rs, DeltaR,rs and Rint,rs) and elastances (Est,rs and Edyn,rs) of respiratory system have been evaluated during costant flow and volume inflation. Inhaled NO (80 ppm, 6') in control conditions increased static and dynamic elastances, while decreased PAPM. PAF administration (50 ng/kg iv) significantly raised respiratory resistances and elastances, and PAPM. Its effects are counterbalanced by inhaled NO. Results show that inhaled NO may represent a therapeutic strategy to reduce bronchoconstriction and pulmonary hypertension present in obstructive, inflammatory and allergic diseases.
Settore VET/02 - Fisiologia Veterinaria
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/182520
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