The acid catalyzed reaction of glycerol-d5 with bromoacetaldehyde dimethyl acetal affords the corresponding 2-bromomethyl-4-hydroxymethyl-1,3-dioxolane, which was treated with lithium iodide in 2-butanone to afford the pentadeuterated domiodol 1 in high isotopic purity.

A FACILE SYNTHESIS OF PENTADEUTERATED DOMIODOL (2-IODOMETHYL-4-HYDROXYMETHYL-1,3-DIOXOLANE) FROM GLYCEROL-1,1,2,3,3-D(5) / P. FERRABOSCHI, P. GRISENTI, E. SANTANIELLO. - In: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. - ISSN 0362-4803. - 34:3(1994), pp. 303-306.

A FACILE SYNTHESIS OF PENTADEUTERATED DOMIODOL (2-IODOMETHYL-4-HYDROXYMETHYL-1,3-DIOXOLANE) FROM GLYCEROL-1,1,2,3,3-D(5)

P. FERRABOSCHI
Primo
;
E. SANTANIELLO
Ultimo
1994

Abstract

The acid catalyzed reaction of glycerol-d5 with bromoacetaldehyde dimethyl acetal affords the corresponding 2-bromomethyl-4-hydroxymethyl-1,3-dioxolane, which was treated with lithium iodide in 2-butanone to afford the pentadeuterated domiodol 1 in high isotopic purity.
deuterium; domiodol; mucolytic drug; synthesis
Settore BIO/10 - Biochimica
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/182500
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