The acid catalyzed reaction of glycerol-d5 with bromoacetaldehyde dimethyl acetal affords the corresponding 2-bromomethyl-4-hydroxymethyl-1,3-dioxolane, which was treated with lithium iodide in 2-butanone to afford the pentadeuterated domiodol 1 in high isotopic purity.
A FACILE SYNTHESIS OF PENTADEUTERATED DOMIODOL (2-IODOMETHYL-4-HYDROXYMETHYL-1,3-DIOXOLANE) FROM GLYCEROL-1,1,2,3,3-D(5) / P. FERRABOSCHI, P. GRISENTI, E. SANTANIELLO. - In: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. - ISSN 0362-4803. - 34:3(1994), pp. 303-306.
Titolo: | A FACILE SYNTHESIS OF PENTADEUTERATED DOMIODOL (2-IODOMETHYL-4-HYDROXYMETHYL-1,3-DIOXOLANE) FROM GLYCEROL-1,1,2,3,3-D(5) |
Autori: | FERRABOSCHI, PATRIZIA (Primo) SANTANIELLO, ENZO (Ultimo) |
Parole Chiave: | deuterium; domiodol; mucolytic drug; synthesis |
Settore Scientifico Disciplinare: | Settore BIO/10 - Biochimica |
Data di pubblicazione: | 1994 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/jlcr.2580340314 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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