Male Fischer F-344 rats were given ethanol in the drinking water and/or by single oral administration. Following this, the animals received p.o. 100 ng/kg of the hepatocarcinogen [3H]aflatoxin B1 (AFB1). 24 h later, the level of DNA-bound AFB1 was determined in the liver and was found not to be affected by any type of ethanol pretreatment. A cocarcinogenic effect of ethanol in the liver is therefore unlikely to due to an effect on the metabolic activation and inactivation processes governing the formation of DNA-binding AFB1 metabolites.
Covalent binding of aflatoxin B1 to liver DNA in rats pretreated with ethanol / M. Marinovich, W.K. Lutz. - In: EXPERIENTIA. - ISSN 0014-4754. - 41:10(1985), pp. 1338-1340. [10.1007/BF01952084]
Covalent binding of aflatoxin B1 to liver DNA in rats pretreated with ethanol
M. MarinovichPrimo
;
1985
Abstract
Male Fischer F-344 rats were given ethanol in the drinking water and/or by single oral administration. Following this, the animals received p.o. 100 ng/kg of the hepatocarcinogen [3H]aflatoxin B1 (AFB1). 24 h later, the level of DNA-bound AFB1 was determined in the liver and was found not to be affected by any type of ethanol pretreatment. A cocarcinogenic effect of ethanol in the liver is therefore unlikely to due to an effect on the metabolic activation and inactivation processes governing the formation of DNA-binding AFB1 metabolites.
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