Arachidonic acid metabolism was evaluated in isolated rat hepatocytes after CCl4 exposure. CCl4 induced dose-dependently the synthesis and release of prostacyclin (PGI2) and thromboxane (TXB2). Treatment with prostaglandin E2 (PGE2) 30 min after exposure to CCl4, significantly reduced the cell damage as well as the release of TXB2 from the cells.
Stimulation of arachidonic acid metabolism by CCl4 in isolated rat hepatocytes / M. Marinovich, L.M. Flamino, M. Papagni, C.L. Galli. - In: PROSTAGLANDINS. - ISSN 0090-6980. - 37:1(1989), pp. 23-31.
Stimulation of arachidonic acid metabolism by CCl4 in isolated rat hepatocytes
M. MarinovichPrimo
;C.L. GalliUltimo
1989
Abstract
Arachidonic acid metabolism was evaluated in isolated rat hepatocytes after CCl4 exposure. CCl4 induced dose-dependently the synthesis and release of prostacyclin (PGI2) and thromboxane (TXB2). Treatment with prostaglandin E2 (PGE2) 30 min after exposure to CCl4, significantly reduced the cell damage as well as the release of TXB2 from the cells.
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