A series of racemic and optically active N-alkylidenesulphinamides has been prepared and their reduction by metal hydrides studied. The extent of asymmetric synthesis mainly depends on the nature of the reducing species; the best results (up to 92% of stereoselectivity) are obtained with alkoxy-lithium aluminium hydrides. A new, highly enantioselective synthesis of amines is described.
Asymmetric induction in the reduction of optically active N-alkylidenesulphinamides by metal hydrides. A new efficient enantioselective route to chiral amines / R. Annunziata, M. Cinquini, F. Cozzi. - In: JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I. - ISSN 0300-922X. - :0(1982), pp. 339-343. [10.1039/P19820000339]
Asymmetric induction in the reduction of optically active N-alkylidenesulphinamides by metal hydrides. A new efficient enantioselective route to chiral amines
R. AnnunziataPrimo
;M. CinquiniSecondo
;F. CozziUltimo
1982
Abstract
A series of racemic and optically active N-alkylidenesulphinamides has been prepared and their reduction by metal hydrides studied. The extent of asymmetric synthesis mainly depends on the nature of the reducing species; the best results (up to 92% of stereoselectivity) are obtained with alkoxy-lithium aluminium hydrides. A new, highly enantioselective synthesis of amines is described.Pubblicazioni consigliate
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