A series of racemic and optically active N-alkylidenesulphinamides has been prepared and their reduction by metal hydrides studied. The extent of asymmetric synthesis mainly depends on the nature of the reducing species; the best results (up to 92% of stereoselectivity) are obtained with alkoxy-lithium aluminium hydrides. A new, highly enantioselective synthesis of amines is described.
Asymmetric induction in the reduction of optically active N-alkylidenesulphinamides by metal hydrides. A new efficient enantioselective route to chiral amines / R. Annunziata, M. Cinquini, F. Cozzi. - In: JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I. - ISSN 0300-922X. - :0(1982), pp. 339-343.
Titolo: | Asymmetric induction in the reduction of optically active N-alkylidenesulphinamides by metal hydrides. A new efficient enantioselective route to chiral amines |
Autori: | ANNUNZIATA, RITA MARIA (Primo) CINQUINI, MAURO (Secondo) COZZI, FRANCO (Ultimo) |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica |
Data di pubblicazione: | 1982 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1039/P19820000339 |
Appare nelle tipologie: | 01 - Articolo su periodico |