[26-3H]Lanosterol (16) was administered to Pinus pinea and the [26-3H]isofucosteryl acetate (6) obtained was chemically transformed into [26-3H]cholesterol (13). Compound (13) was incubated with rat-liver mitochondria to yield [3-3H] propionic acid. The data obtained are consistent with a biosynthetic pathway in which the pro-E isopropylidene methyl group of the Δ24-precursor becomes the pro-R isopropyl methyl group in isofucosterol.
Stereochemical fate of the isopropylidene methyl groups of lanosterol during the biosynthesis of isofucosterol in Pinus pinea / F. Nicotra, F. Ronchetti, G. Russo, G. Lugaro, M. Casellato. - In: JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I. - ISSN 0300-922X. - :0(1981), pp. 498-502.
Stereochemical fate of the isopropylidene methyl groups of lanosterol during the biosynthesis of isofucosterol in Pinus pinea
F. RonchettiSecondo
;G. Russo;
1981
Abstract
[26-3H]Lanosterol (16) was administered to Pinus pinea and the [26-3H]isofucosteryl acetate (6) obtained was chemically transformed into [26-3H]cholesterol (13). Compound (13) was incubated with rat-liver mitochondria to yield [3-3H] propionic acid. The data obtained are consistent with a biosynthetic pathway in which the pro-E isopropylidene methyl group of the Δ24-precursor becomes the pro-R isopropyl methyl group in isofucosterol.
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