The chromatographic separation of 33 neurochemicals was achieved by using a combined gradient of organic modifier, pH and counter-ion. A secondary separation of unresolved analytes was obtained by using electrochemical detection with a coulometric array of sixteen electrodes. The stability of the analytes was studied and data on analytical performance are reported in addition to a list of neurochemicals detected in a normal plasma sample.
Determination of neurochemicals in biological fluids by using an automated high-performance liquid chromatographic system with a coulometric array detector / V. Rizzo, G. Melzi d'Eril, G. Achilli, G.P. Cellerino. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 0021-9673. - 536:1-2(1991 Jan 04), pp. 229-236. [10.1016/S0021-9673(01)89254-2]
Determination of neurochemicals in biological fluids by using an automated high-performance liquid chromatographic system with a coulometric array detector
G. Melzi d'ErilSecondo
;
1991
Abstract
The chromatographic separation of 33 neurochemicals was achieved by using a combined gradient of organic modifier, pH and counter-ion. A secondary separation of unresolved analytes was obtained by using electrochemical detection with a coulometric array of sixteen electrodes. The stability of the analytes was studied and data on analytical performance are reported in addition to a list of neurochemicals detected in a normal plasma sample.
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