Five fractions of an aqueous extract obtained from the roots of Echinacea angustifolia were separated on the basis of molecular weight. The topical anti-inflammatory activity of the fractions has been evaluated in mice using the Croton oil ear test. The fraction with a molecular weight between 30,000 and 100,000 was the most active in inhibiting the oedema; it also reduced the infiltration of inflammatory cells. The activity of this fraction was comparable with that of a raw polysaccharidic extract obtained from E. angustifolia roots by differential solubility. The high-molecular weight polysaccharides are therefore proposed as the anti-inflammatory principles of the plant.
|Titolo:||Anti-inflammatory activity of Echinacea angustifolia fractions separated on the basis of molecular weight|
TRAGNI, ELENA CLELIA GIUSEPPINA (Primo)
GALLI, CORRADO LODOVICO (Secondo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||dic-1988|
|Digital Object Identifier (DOI):||10.1016/S0031-6989(88)80848-8|
|Appare nelle tipologie:||01 - Articolo su periodico|