1. [28-3H]Stigmast-5-ene-3 beta, 28-diol and [23,23,25-3H]stigmast-5-ene-3 beta, 24-diol were synthesized. 2. Each of the samples was mixed with beta-[4-14C]sitosterol and administered to Tenebrio molitor larvae. 3. The former compound is not utilized by the insect; the latter, although metabolized to 24(28)-ethylidene sterols and cholesterol, is not a beta-sitosterol metabolite. 4. The above results are discussed in relation to the mechanism of formation of the 24(28)-double bond in beta-sitosterol metabolism in T. molitor.

Role of 24- and 28-hydroxylated intermediates in the metabolism of β-sitosterol in the insect Tenebrio molitor / F. Nicotra, F. Ronchetti, G. Russo, L. Toma. - In: BIOCHEMICAL JOURNAL. MOLECULAR ASPECTS. - ISSN 0306-3275. - 183:3(1979), pp. 495-499.

Role of 24- and 28-hydroxylated intermediates in the metabolism of β-sitosterol in the insect Tenebrio molitor

F. Ronchetti
Secondo
;
G. Russo
Penultimo
;
1979

Abstract

1. [28-3H]Stigmast-5-ene-3 beta, 28-diol and [23,23,25-3H]stigmast-5-ene-3 beta, 24-diol were synthesized. 2. Each of the samples was mixed with beta-[4-14C]sitosterol and administered to Tenebrio molitor larvae. 3. The former compound is not utilized by the insect; the latter, although metabolized to 24(28)-ethylidene sterols and cholesterol, is not a beta-sitosterol metabolite. 4. The above results are discussed in relation to the mechanism of formation of the 24(28)-double bond in beta-sitosterol metabolism in T. molitor.
Settore BIO/10 - Biochimica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182263
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