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EnglishA B cell lymphoma-associated chromosomal translocation, t(10;14)(q24;q32), juxtaposes the immunoglobulin C alpha 1 locus to a novel gene, lyt-10. The normal lyt-10 cDNA codes for a 98 kd protein which displays amino-terminal homology with the rel (DNA-binding) domain of the NF-kappa B-rel family of transcription factors and carboxy-terminal homology with the NF-kappa B p50 precursor protein, including the putative proteolytic cleavage domain (poly-G) and the ankyrin-like repeat domains. The lyt-10 protein can bind to kappa B sequences in vitro, although with different specificity from NF-kappa B p50, and in vitro DNA-binding is activated by removal of the ankyrin domain. Chromosomal translocation generates an lyt-10-C alpha 1 fusion gene coding for a protein that retains the rel effector domain, lacks the ankyrin regulatory domain, and binds kappa B sequences in vitro, suggesting its constitutive activation in vivo. Analogous rearrangements of the lyt-10 gene have been found in an additional three cases of lymphoid neoplasia. The lyt-10 gene defines a new subfamily (rel/poly-G/ankyrin) of NF-kappa B-rel transcription factors with potential for oncogenic activation in human cancer.
B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50 / A. Neri, C. C. Chang, L. Lombardi, M. Salina, P. Corradini, A. T. Maiolo, R. S. Chaganti, R. Dalla-Favera. - In: CELL. - ISSN 0092-8674. - 67:6(1991 Dec 20), pp. 1075-87-1087.
| Titolo: | B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50 |
| Autori: | NERI, ANTONINO (Primo) |
| Parole Chiave: | NF-kappa B; Oligodeoxyribonucleotides; Multigene Family; DNA-Binding Proteins; Humans; Chromosomes, Human, Pair 10; Genes, Immunoglobulin; Gene Expression; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Amino Acid Sequence; Chromosomes, Human, Pair 14; Translocation, Genetic; Cloning, Molecular; RNA, Messenger; Lymphoma, B-Cell; Regulatory Sequences, Nucleic Acid; Polymerase Chain Reaction; Base Sequence; Oncogenes; Transcription Factors; Restriction Mapping; Molecular Sequence Data; DNA; Immunoglobulin alpha-Chains |
| Settore Scientifico Disciplinare: | Settore MED/15 - Malattie del Sangue |
| Data di pubblicazione: | 20-dic-1991 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/0092-8674(91)90285-7 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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