The myelin sheaths that surround all but the smallest diameter axons within the mammalian central nervous system (CNS) must maintain their structural integrity for many years. Like many tissues, however, this function is prone to the effects of ageing, and various structural anomalies become apparent in the aged CNS. Similarly, the regenerative process by which myelin sheaths, lost as a consequence of exposure to a demyelinating insult, are restored (remyelination) is also affected by age. As animals grow older, the efficiency of remyelination progressively declines. In this article, we review both phenomena and describe how both can be partially reversed by steroid hormones and their derivatives.

Steroids and the reversal of age-associated changes in myelination and remyelination / C. Ibanez, S.A. Shields, M. El-Etr, E. Leonelli, V. Magnaghi, W. Li, F.J. Sim, E. Baulieu, R.C. Melcangi, M. Schumacher, R.J.M. Franklin. - In: PROGRESS IN NEUROBIOLOGY. - ISSN 0301-0082. - 71:1(2003 Sep), pp. 49-56.

Steroids and the reversal of age-associated changes in myelination and remyelination

E. Leonelli;V. Magnaghi;R.C. Melcangi;
2003

Abstract

The myelin sheaths that surround all but the smallest diameter axons within the mammalian central nervous system (CNS) must maintain their structural integrity for many years. Like many tissues, however, this function is prone to the effects of ageing, and various structural anomalies become apparent in the aged CNS. Similarly, the regenerative process by which myelin sheaths, lost as a consequence of exposure to a demyelinating insult, are restored (remyelination) is also affected by age. As animals grow older, the efficiency of remyelination progressively declines. In this article, we review both phenomena and describe how both can be partially reversed by steroid hormones and their derivatives.
Animals ; Progesterone ; Nerve Regeneration ; Humans ; Aging ; Myelin Sheath ; Central Nervous System ; Steroids
Settore MED/13 - Endocrinologia
Settore BIO/09 - Fisiologia
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182173
Citazioni
  • ???jsp.display-item.citation.pmc??? 20
  • Scopus 75
  • ???jsp.display-item.citation.isi??? 66
social impact