The myelin sheaths that surround all but the smallest diameter axons within the mammalian central nervous system (CNS) must maintain their structural integrity for many years. Like many tissues, however, this function is prone to the effects of ageing, and various structural anomalies become apparent in the aged CNS. Similarly, the regenerative process by which myelin sheaths, lost as a consequence of exposure to a demyelinating insult, are restored (remyelination) is also affected by age. As animals grow older, the efficiency of remyelination progressively declines. In this article, we review both phenomena and describe how both can be partially reversed by steroid hormones and their derivatives.
Steroids and the reversal of age-associated changes in myelination and remyelination / C. Ibanez, S.A. Shields, M. El-Etr, E. Leonelli, V. Magnaghi, W. Li, F.J. Sim, E. Baulieu, R.C. Melcangi, M. Schumacher, R.J.M. Franklin. - In: PROGRESS IN NEUROBIOLOGY. - ISSN 0301-0082. - 71:1(2003 Sep), pp. 49-56.
|Titolo:||Steroids and the reversal of age-associated changes in myelination and remyelination|
|Parole Chiave:||Animals ; Progesterone ; Nerve Regeneration ; Humans ; Aging ; Myelin Sheath ; Central Nervous System ; Steroids|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
Settore BIO/09 - Fisiologia
|Data di pubblicazione:||set-2003|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.pneurobio.2003.09.002|
|Appare nelle tipologie:||01 - Articolo su periodico|