We report the presence of serum autoantibodies directed against glutamic acid decarboxylase in a patient with epilepsy and palatal myoclonus not associated with brain lesions. Glutamic acid decarboxylase antibody reactivity was dependent on the presence of carboxy-terminal amino acids, similar to that reported in patients with stiff-man syndrome. Marked reduction in the frequency of epileptic attacks and improvement in palatal myoclonus occurred when benzodiazepine was administered and phenytoin was gradually tapered. Testing for anti-glutamic acid decarboxylase antibodies may be indicated in patients with palatal myoclonus and with convulsive disorders refractory to therapy.
Autoantibodies to glutamic acid decarboxylase in palatal myoclonus and epilepsy / R. Nemni, S. Braghi, M. G. Natali-Sora, V. Lampasona, E. Bonifacio, G. Comi, N. Canal. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 36:4(1994 Oct), pp. 665-7-667.
|Titolo:||Autoantibodies to glutamic acid decarboxylase in palatal myoclonus and epilepsy|
NEMNI, RAFFAELLO (Primo)
|Parole Chiave:||Epilepsy, Complex Partial; Myoclonus; Antibodies; Humans; Adult; Glutamate Decarboxylase; Palate, Soft; Female|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
Settore MED/31 - Otorinolaringoiatria
|Data di pubblicazione:||ott-1994|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/ana.410360419|
|Appare nelle tipologie:||01 - Articolo su periodico|