The present paper will summarize two important aspects of the interactions between steroids and the brain, which have recently been studied in the authors' laboratory. In particular the paper will consider data on: (1) the significance of the two isoforms of the 5alpha-R during brain ontogenesis and development, and (2) the cross-talk between glial and neuronal elements, particularly in relation to the metabolism of sex hormones. (1) The data obtained have shown that the 5alpha-R type 1 enzyme is constitutively expressed in the rat CNS at all stages of brain development. Moreover, the expression of the 5alpha-R type 1 is similar in males and in females, and does not appear to be controlled by androgens. The gene expression of the 5alpha-R type 2 is totally different. This isoform appears to be expressed in the rat brain almost exclusively in the late fetal/early post-natal life and is controlled by testosterone. (2) The present data show that two cell lines derived respectively from a rat glioma (C6 cell line) and from a human astrocytoma (1321N1 cell line) are able to convert testosterone and progesterone into their corresponding 5alpha-reduced metabolites dihydrotestosterone and dihydroprogesterone. The possibility that secretory products of normal and tumoral brain cells might be able to influence steroid metabolism occurring in the two glial cell lines previously mentioned has been considered.

The 5alpha-reductase in the central nervous system: expression and modes of control / R.C. Melcangi, A. Poletti, I. Cavarretta, F. Celotti, A. Colciago, V. Magnaghi, M. Motta, P. Negri-Cesi, L. Martini. - In: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. - ISSN 0960-0760. - 65:1-6(1998 Apr), pp. 295-299. ((Intervento presentato al 13. convegno Proceedings of the International Symposium of the Journal of Steroid Biochemistry and Molecular Biology tenutosi a Monaco nel 1997.

The 5alpha-reductase in the central nervous system: expression and modes of control

R.C. Melcangi
Primo
;
A. Poletti
Secondo
;
F. Celotti;A. Colciago;V. Magnaghi;M. Motta;P. Negri-Cesi
Penultimo
;
L. Martini
Ultimo
1998-04

Abstract

The present paper will summarize two important aspects of the interactions between steroids and the brain, which have recently been studied in the authors' laboratory. In particular the paper will consider data on: (1) the significance of the two isoforms of the 5alpha-R during brain ontogenesis and development, and (2) the cross-talk between glial and neuronal elements, particularly in relation to the metabolism of sex hormones. (1) The data obtained have shown that the 5alpha-R type 1 enzyme is constitutively expressed in the rat CNS at all stages of brain development. Moreover, the expression of the 5alpha-R type 1 is similar in males and in females, and does not appear to be controlled by androgens. The gene expression of the 5alpha-R type 2 is totally different. This isoform appears to be expressed in the rat brain almost exclusively in the late fetal/early post-natal life and is controlled by testosterone. (2) The present data show that two cell lines derived respectively from a rat glioma (C6 cell line) and from a human astrocytoma (1321N1 cell line) are able to convert testosterone and progesterone into their corresponding 5alpha-reduced metabolites dihydrotestosterone and dihydroprogesterone. The possibility that secretory products of normal and tumoral brain cells might be able to influence steroid metabolism occurring in the two glial cell lines previously mentioned has been considered.
Rats ; Animals ; Age Factors ; Neuroglia ; Neurons ; Isoenzymes ; Brain ; Cell Communication ; Gene Expression Regulation ; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase ; Male ; Female
Settore BIO/09 - Fisiologia
Settore BIO/13 - Biologia Applicata
Settore MED/04 - Patologia Generale
Settore MED/13 - Endocrinologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/182127
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