Starting from 5-unsubstituted or 5-alkyl-, aryl-, heteroarylsubstituted 3-diethylamino-4-arylisothiazole 1,1- dioxides by base induced ring opening 3-alkoxypropenamidines were synthesized in excellent yields in a mild and efficient way. When 5-bromo-3-diethylamino-4-arylisothiazole 1,1-dioxide was used as the reagent, 3,3-dialkoxy-propenamidines, a new class of unsaturated amidines, were obtained. By using Grignard reagents 3-substituted acrylamidines can be produced.

Isothiazoles. Part X. New 3-substituted-2-arylpropenamidines by base catalyzed ring opening of 3-amino-4-arylisothiazole 1,1- dioxides / E.M. Beccalli, F. Clerici, M.L. Gelmi. - In: TETRAHEDRON. - ISSN 0040-4020. - 55:52(1999), pp. 14975-14984.

Isothiazoles. Part X. New 3-substituted-2-arylpropenamidines by base catalyzed ring opening of 3-amino-4-arylisothiazole 1,1- dioxides

E.M. Beccalli
Primo
;
F. Clerici
Secondo
;
M.L. Gelmi
Ultimo
1999

Abstract

Starting from 5-unsubstituted or 5-alkyl-, aryl-, heteroarylsubstituted 3-diethylamino-4-arylisothiazole 1,1- dioxides by base induced ring opening 3-alkoxypropenamidines were synthesized in excellent yields in a mild and efficient way. When 5-bromo-3-diethylamino-4-arylisothiazole 1,1-dioxide was used as the reagent, 3,3-dialkoxy-propenamidines, a new class of unsaturated amidines, were obtained. By using Grignard reagents 3-substituted acrylamidines can be produced.
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/182126
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