A simple method to introduce an heteroatom substituent at C-5 of isothiazole dioxides is reported. Through Michael addition reactin 5- substituted isothiazole and 4,5-dihydroisothiazole 1,1-dioxides were obtained allowing the preparation of a series of derivatives of special interst for biological studies.
Isothiazoles. Part IX. An efficient synthetic route to 5-substituted-3- amino-4-arylisothiazole 1,1-dioxides and their 4,5-dihydro derivatives / E.M. Beccalli, F. Clerici, M.L. Gelmi. - In: TETRAHEDRON. - ISSN 0040-4020. - 55:7(1999), pp. 2001-2012.
Isothiazoles. Part IX. An efficient synthetic route to 5-substituted-3- amino-4-arylisothiazole 1,1-dioxides and their 4,5-dihydro derivatives
E.M. BeccalliPrimo
;F. ClericiSecondo
;M.L. GelmiUltimo
1999
Abstract
A simple method to introduce an heteroatom substituent at C-5 of isothiazole dioxides is reported. Through Michael addition reactin 5- substituted isothiazole and 4,5-dihydroisothiazole 1,1-dioxides were obtained allowing the preparation of a series of derivatives of special interst for biological studies.
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