A simple method to introduce an heteroatom substituent at C-5 of isothiazole dioxides is reported. Through Michael addition reactin 5- substituted isothiazole and 4,5-dihydroisothiazole 1,1-dioxides were obtained allowing the preparation of a series of derivatives of special interst for biological studies.

Isothiazoles. Part IX. An efficient synthetic route to 5-substituted-3- amino-4-arylisothiazole 1,1-dioxides and their 4,5-dihydro derivatives / E.M. Beccalli, F. Clerici, M.L. Gelmi. - In: TETRAHEDRON. - ISSN 0040-4020. - 55:7(1999), pp. 2001-2012.

Isothiazoles. Part IX. An efficient synthetic route to 5-substituted-3- amino-4-arylisothiazole 1,1-dioxides and their 4,5-dihydro derivatives

E.M. Beccalli
Primo
;
F. Clerici
Secondo
;
M.L. Gelmi
Ultimo
1999

Abstract

A simple method to introduce an heteroatom substituent at C-5 of isothiazole dioxides is reported. Through Michael addition reactin 5- substituted isothiazole and 4,5-dihydroisothiazole 1,1-dioxides were obtained allowing the preparation of a series of derivatives of special interst for biological studies.
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182108
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