Enzymatic transesterification, mediated by Pseudomonas cepacia lipase (lipase PS), led to the pure 1,6′-diacylderivatives of 2-O-β-D-glucosyl-sn-glycerol and 2-O-β-D-galactosyl-sn-glycerol, the acyl chains being derived from short-medium length fatty acids. A study of the in vitro inhibitory effects of these diacylderivatives on Epstein-Barr virus early antigen activation induced by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate revealed that maximum activity was reached for the hexanoyl chain and that the introduction of a second acyl chain did not significantly modify the inhibitory potential referring to the corresponding 1- or 6′-monoesters.
Diesters of glycosylglycerols active in cancer chemoprevention / D. Colombo, F. Compostella, F. Ronchetti, A. Scala, H. Tokuda, H. Nishino. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 36:7-8(2001), pp. 691-695.
Diesters of glycosylglycerols active in cancer chemoprevention
D. ColomboPrimo
;F. CompostellaSecondo
;F. Ronchetti;A. Scala;
2001
Abstract
Enzymatic transesterification, mediated by Pseudomonas cepacia lipase (lipase PS), led to the pure 1,6′-diacylderivatives of 2-O-β-D-glucosyl-sn-glycerol and 2-O-β-D-galactosyl-sn-glycerol, the acyl chains being derived from short-medium length fatty acids. A study of the in vitro inhibitory effects of these diacylderivatives on Epstein-Barr virus early antigen activation induced by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate revealed that maximum activity was reached for the hexanoyl chain and that the introduction of a second acyl chain did not significantly modify the inhibitory potential referring to the corresponding 1- or 6′-monoesters.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.