Four glycoglycerolipid analogues, 1-O-hexanoyl-2-O-β-D-glucopyranosyl-sn-glycerol (1), 1-O-hexanoyl-2-O-β-D-galactopyranosyl-sn-glycerol (2), 2-O-(6-O-hexanoyl-β-D-galactopyranosyl)-sn-glycerol (3) and 2-O-(6-O-hexanoyl-α-D-galactopyranosyl)-sn-glycerol (4), potent in vitro inhibitors of 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation, were submitted to an in vivo two-stage mouse skin carcinogenesis test, using dimethylbenz[a]anthracene (DMBA) and TPA. The study was extended to two deacylated galactosylglycerol structures, 1-O-β-D-galactopyranosyl-sn-glycerol (5) and 3-O-β-D-galactopyranosyl-sn-glycerol (6). All the tested compounds exhibited remarkable anti-tumor-promoting effects on mouse skin tumor promotion, the 1-hexanoate 2 being the most active among the glycoglycerolipids until now studied. (C) 2000 Elsevier Science Ireland Ltd.

Anti-tumor-promoting effects of glycoglycerolipid analogues on two-stage mouse skin carcinogenesis / D. Colombo, F. Compostella, F. Ronchetti, A. Scala, L. Toma, M. Kuchide, H. Tokuda, H. Nishino. - In: CANCER LETTERS. - ISSN 0304-3835. - 161:2(2000), pp. 201-205.

Anti-tumor-promoting effects of glycoglycerolipid analogues on two-stage mouse skin carcinogenesis

D. Colombo
Primo
;
F. Compostella
Secondo
;
F. Ronchetti;A. Scala;
2000

Abstract

Four glycoglycerolipid analogues, 1-O-hexanoyl-2-O-β-D-glucopyranosyl-sn-glycerol (1), 1-O-hexanoyl-2-O-β-D-galactopyranosyl-sn-glycerol (2), 2-O-(6-O-hexanoyl-β-D-galactopyranosyl)-sn-glycerol (3) and 2-O-(6-O-hexanoyl-α-D-galactopyranosyl)-sn-glycerol (4), potent in vitro inhibitors of 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation, were submitted to an in vivo two-stage mouse skin carcinogenesis test, using dimethylbenz[a]anthracene (DMBA) and TPA. The study was extended to two deacylated galactosylglycerol structures, 1-O-β-D-galactopyranosyl-sn-glycerol (5) and 3-O-β-D-galactopyranosyl-sn-glycerol (6). All the tested compounds exhibited remarkable anti-tumor-promoting effects on mouse skin tumor promotion, the 1-hexanoate 2 being the most active among the glycoglycerolipids until now studied. (C) 2000 Elsevier Science Ireland Ltd.
Glycoglycerolipids analogues; Skin tumor, Anti-tumor-promoting effect
Settore BIO/10 - Biochimica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182057
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