The in vitro anti-tumor promoting effect of monohexanoates of 2-O-α-D-gluco- and galactopyranosyl-sn-glycerol on the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation was evaluated and compared to the potencies of the corresponding β-anomers. The results show that the inversion of the anomeric configuration from β to α does not seem to significantly influence the activity, which is present, as for the β-anomers, even at 1 × 10 mol ratio without any cytotoxicity.
Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration / D. Colombo, F. Compostella, F. Ronchetti, A. Scala, L. Toma, H. Tokuda, H. Nishino. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 35:12(2000), pp. 1109-1113.
Titolo: | Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration |
Autori: | COLOMBO, DIEGO RODOLFO (Primo) COMPOSTELLA, FEDERICA (Secondo) |
Parole Chiave: | Anti-tumor-promoting activity; Cancer chemoprevention; Epstein-Barr virus activation test; Glycoglycerolipid analogues |
Settore Scientifico Disciplinare: | Settore BIO/10 - Biochimica |
Data di pubblicazione: | 2000 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0223-5234(00)01193-4 |
Appare nelle tipologie: | 01 - Articolo su periodico |