The in vitro anti-tumor promoting effect of monohexanoates of 2-O-α-D-gluco- and galactopyranosyl-sn-glycerol on the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation was evaluated and compared to the potencies of the corresponding β-anomers. The results show that the inversion of the anomeric configuration from β to α does not seem to significantly influence the activity, which is present, as for the β-anomers, even at 1 × 10 mol ratio without any cytotoxicity.
Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration / D. Colombo, F. Compostella, F. Ronchetti, A. Scala, L. Toma, H. Tokuda, H. Nishino. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 35:12(2000), pp. 1109-1113.
Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration
D. ColomboPrimo
;F. CompostellaSecondo
;F. Ronchetti;A. Scala;
2000
Abstract
The in vitro anti-tumor promoting effect of monohexanoates of 2-O-α-D-gluco- and galactopyranosyl-sn-glycerol on the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation was evaluated and compared to the potencies of the corresponding β-anomers. The results show that the inversion of the anomeric configuration from β to α does not seem to significantly influence the activity, which is present, as for the β-anomers, even at 1 × 10 mol ratio without any cytotoxicity.
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