2-O-β-D-Galactosylglycerol 1 was submitted to acylation using Pseudomonas cepacia or Candida antarctica lipases as catalysts and 2,2,2- trifluoroethyl esters of butanoic, hexanoic, octanoic or decanoic acid as acyl carriers. Taking advantage of the high diastereoselectivity and regioselectivity of the two enzymes, the 1-O-, 3-O-, 6'-O-acyl and the 1,6'- di-O-acylderivatives of 1 were obtained pure or in an appreciably enriched form.

Bioctive glycoglycerolipid analogues: an expeditious enzymatic approach to mono- and diesters of 2-O-beta-D-galactoglycerol / D. Colombo, F. Ronchetti, A. Scala, L. Toma. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 9:12(1998), pp. 2113-2119. [10.1016/S0957-4166(98)00207-9]

Bioctive glycoglycerolipid analogues: an expeditious enzymatic approach to mono- and diesters of 2-O-beta-D-galactoglycerol

D. Colombo
Primo
;
F. Ronchetti
Secondo
;
A. Scala
Penultimo
;
1998

Abstract

2-O-β-D-Galactosylglycerol 1 was submitted to acylation using Pseudomonas cepacia or Candida antarctica lipases as catalysts and 2,2,2- trifluoroethyl esters of butanoic, hexanoic, octanoic or decanoic acid as acyl carriers. Taking advantage of the high diastereoselectivity and regioselectivity of the two enzymes, the 1-O-, 3-O-, 6'-O-acyl and the 1,6'- di-O-acylderivatives of 1 were obtained pure or in an appreciably enriched form.
Settore BIO/10 - Biochimica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/182045
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