Subcutaneous injections of naloxone, an opiate antagonist, lead to an increase in serum luteinizing hormone concentrations in female but not in male rats before they reach puberty. In addition, estradiol benzoate specifically blocks the luteinizing hormone response to naloxone in prepubertal female rats, suggesting that the opioid peptides have a physiological role in the endocrine events leading to sexual maturation.

opioid peptides modulate luteinizing hormone secretion during sexual maturation / M.S. Blank, A.E. Panerai, H.G. Friesen. - In: SCIENCE. - ISSN 0036-8075. - 203:4385(1979), pp. 1129-1131.

opioid peptides modulate luteinizing hormone secretion during sexual maturation

A.E. Panerai
Secondo
;
1979

Abstract

Subcutaneous injections of naloxone, an opiate antagonist, lead to an increase in serum luteinizing hormone concentrations in female but not in male rats before they reach puberty. In addition, estradiol benzoate specifically blocks the luteinizing hormone response to naloxone in prepubertal female rats, suggesting that the opioid peptides have a physiological role in the endocrine events leading to sexual maturation.
Settore BIO/14 - Farmacologia
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/181907
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 188
  • ???jsp.display-item.citation.isi??? 248
social impact