To extend the knowledge on the central effects of cytokines, we studied the effects of tumor necrosis factor α and interleukin-1α on nociceptive thresholds and spontaneous locomotor activity in rats. After central administration, both tumor necrosis factor α and interleukin-1α significantly (P<0.001) increase the nociceptive thresholds as measured by the hot-plate test. Tumor necrosis factor α, but not interleukin-1α decreases spontaneous locomotor activity evaluated by the Animex test. The increase in nociceptive thresholds induced by tumor necrosis factor α or interleukin-1α is not affected by the opiate receptor antagonist naloxone, or antisera against the endogenous opioids β-endorphin, met-enkephalin or dynorphin. The analgesic effect of tumor necrosis factor α is completely antagonized by anti-IL-1 antibodies. Moreover, the cyclooxygenase inhibitor indomethacin does not antagonize the increase of nociceptive thresholds induced by either cytokine.

Central effects of tumor factor alfa and interleukin-1a on nociceptive thresholds and spontaneous locomotor activity / M.Bianchi, P. Sacerdote, P. Ricciardi-Castagnoli, P. Mantegazza, A.E. Panerai. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 148:1-2(1992), pp. 76-80.

Central effects of tumor factor alfa and interleukin-1a on nociceptive thresholds and spontaneous locomotor activity

M.Bianchi
Primo
;
P. Sacerdote
Secondo
;
A.E. Panerai
Ultimo
1992

Abstract

To extend the knowledge on the central effects of cytokines, we studied the effects of tumor necrosis factor α and interleukin-1α on nociceptive thresholds and spontaneous locomotor activity in rats. After central administration, both tumor necrosis factor α and interleukin-1α significantly (P<0.001) increase the nociceptive thresholds as measured by the hot-plate test. Tumor necrosis factor α, but not interleukin-1α decreases spontaneous locomotor activity evaluated by the Animex test. The increase in nociceptive thresholds induced by tumor necrosis factor α or interleukin-1α is not affected by the opiate receptor antagonist naloxone, or antisera against the endogenous opioids β-endorphin, met-enkephalin or dynorphin. The analgesic effect of tumor necrosis factor α is completely antagonized by anti-IL-1 antibodies. Moreover, the cyclooxygenase inhibitor indomethacin does not antagonize the increase of nociceptive thresholds induced by either cytokine.
Central nervous system; Cytokine; Hot-plate; Interleukin-1α; Locomotor activity; Nociceptive threshold; Rat; Tumor necrosis factor α
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181899
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