To extend the knowledge on the central effects of cytokines, we studied the effects of tumor necrosis factor α and interleukin-1α on nociceptive thresholds and spontaneous locomotor activity in rats. After central administration, both tumor necrosis factor α and interleukin-1α significantly (P<0.001) increase the nociceptive thresholds as measured by the hot-plate test. Tumor necrosis factor α, but not interleukin-1α decreases spontaneous locomotor activity evaluated by the Animex test. The increase in nociceptive thresholds induced by tumor necrosis factor α or interleukin-1α is not affected by the opiate receptor antagonist naloxone, or antisera against the endogenous opioids β-endorphin, met-enkephalin or dynorphin. The analgesic effect of tumor necrosis factor α is completely antagonized by anti-IL-1 antibodies. Moreover, the cyclooxygenase inhibitor indomethacin does not antagonize the increase of nociceptive thresholds induced by either cytokine.
Central effects of tumor factor alfa and interleukin-1a on nociceptive thresholds and spontaneous locomotor activity / M.Bianchi, P. Sacerdote, P. Ricciardi-Castagnoli, P. Mantegazza, A.E. Panerai. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 148:1-2(1992), pp. 76-80.
|Titolo:||Central effects of tumor factor alfa and interleukin-1a on nociceptive thresholds and spontaneous locomotor activity|
BIANCHI, MAURO (Primo)
SACERDOTE, PAOLA GIUSEPPINA (Secondo)
PANERAI, ALBERTO EMILIO (Ultimo)
|Parole Chiave:||Central nervous system; Cytokine; Hot-plate; Interleukin-1α; Locomotor activity; Nociceptive threshold; Rat; Tumor necrosis factor α|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1992|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0304-3940(92)90808-K|
|Appare nelle tipologie:||01 - Articolo su periodico|