The proopiomelanocortin-derived peptide α-melanocyte stimulating hormone (α-MSH) has potent anti-inflammatory effects in all animal models of inflammation against which it has been tested. Understanding of the mechanism by which this occurs is incomplete, although there is recent evidence for α-MSH receptors in murine and human macrophages and for modulation of production of proinflammatory cytokines and related mediators by α-MSH. Because of the prominence of neutrophils in early stages of inflammatory reactions where α-MSH is effective, we examined human neutrophils for evidence of mRNA for α-MSH receptors and for inhibition of neutrophil chemotaxis. There was accumulation of mRNA for melanocortin receptor 1 (MC1) in RT/PCR product from neutrophils stimulated with interferon and LPS. In subsequent studies α-MSH inhibited migration of neutrophils from most normal volunteers when the cells were placed in FMLP or IL-8 gradients. The inhibition by α-MSH could be traced to alterations in cAMP in neutrophils. The presence of α-MSH receptor message in neutrophils is consistent with the established anti-inflammatory effects of the peptide. Direct inhibition of neutrophil chemotaxis likely contributes to the anti-inflammatory activity of α-MSH.
The neuropeptide -MSH has specific receptors on neutrophils and reduces chemotaxis in vitro / A. Catania, N. Rajora, F. Capsoni, F. Minonzio, R.A. Star,J.M. Lipton.. - In: PEPTIDES. - ISSN 0196-9781. - 17:4(1996), pp. 675-679.
Titolo: | The neuropeptide -MSH has specific receptors on neutrophils and reduces chemotaxis in vitro | |
Autori: | ||
Parole Chiave: | α-MSH; Cytokines; Inflammation; Melanocortin receptors; Neutrophil chemotaxis | |
Settore Scientifico Disciplinare: | Settore MED/16 - Reumatologia | |
Data di pubblicazione: | 1996 | |
Rivista: | ||
Tipologia: | Article (author) | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/0196-9781(96)00037-X | |
Appare nelle tipologie: | 01 - Articolo su periodico |