We examined the effect of chronic opiate treatment on the alpha 2-adrenergic receptor binding of both the agonist [3H]clonidine and the antagonist [3H]yohimbine in the cerebral cortex and kidney of rats. In addition, we demonstrated the presence of an adrenergic receptor of the alpha 2 type on the neurotumor cell line NCB20 and used this cell line as a model for studying the interaction between the opiate and alpha 2-adrenergic systems. In all the three above systems, chronic opiate treatment did not modify the number or the affinity of alpha 2-adrenergic receptors.

Chronic opiate treatment does not modify alpha 2-adrenergic receptors in rat cerebral cortex, kidney and in the neurotumor cell line NCB20 / L. M. Vicentini, R. J. Miller, M. J. Robertson. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 95:3-4(1983 Nov 25), pp. 265-270. [10.1016/0014-2999(83)90644-1]

Chronic opiate treatment does not modify alpha 2-adrenergic receptors in rat cerebral cortex, kidney and in the neurotumor cell line NCB20

L.M. Vicentini
Primo
;
1983

Abstract

We examined the effect of chronic opiate treatment on the alpha 2-adrenergic receptor binding of both the agonist [3H]clonidine and the antagonist [3H]yohimbine in the cerebral cortex and kidney of rats. In addition, we demonstrated the presence of an adrenergic receptor of the alpha 2 type on the neurotumor cell line NCB20 and used this cell line as a model for studying the interaction between the opiate and alpha 2-adrenergic systems. In all the three above systems, chronic opiate treatment did not modify the number or the affinity of alpha 2-adrenergic receptors.
Rats, Inbred Strains; Rats; Animals; Clonidine; Yohimbine; Kidney; Brain; Narcotics; Time Factors; Receptors, Adrenergic, alpha; Male; Cell Line
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181851
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